2x01 - In My Time Of Dying

Dean : Come on, Sam. Go find some hoodoo priest to lay some mojo on me.

Dean : [To John who cant hear him] Come on, Dad. You've gotta help me. I've gotta get better, I've gotta get back in there. I mean, you haven't called a soul for help. You haven't even tried. Aren't you going to do anything? Aren't you even going to say anything? I've done everything you've ever asked me. Everything. I have given everything I've ever had. And you're just going to sit there and you're going to watch me die? I mean, what the hell kind of father are you?

Dean : Dude, I full-on Swayze'd that mother.

John : [To Sam] Can we not fight? You know, half the time we're fighting, I don't know what we're fighting about. We're just butting heads. Sammy, I, I've made some mistakes. But I've always done the best I could. I just don't want to fight anymore, okay?

John : [To Dean] You know, when you were a kid, I'd come home from a hunt, and after what I'd seen, I'd be, I'd be wrecked. And you, you'd come up to me and you, you'd put your hand on my shoulder and you'd look me in the eye and you'd... You'd say "It's okay, Dad" Dean, I'm sorry. [...] You shouldn't have had to say that to me, I should have been saying that to you. You know, I put, I put too much on your shoulders, I made you grow up too fast. You took care of Sammy, you took care of me. You did that, and you didn't complain, not once. I just want you to know that I am so proud of you.

Doctor : I'll call it. Time of death - 10:41 am.

2x02 - Everybody Loves A Clown

Dean : This is humiliating. I feel like a friggin' soccer mom!

Ash : There are non-parametrics, statistical overviews, prospects and correlations, I mean.. damn! They're signs. Omens. Uh, if you can track 'em, you can track this demon. You know, like crop failures, electrical storms... You ever been struck by lightening? It ain't fun.

Jo : Most hunters come through that door think they can get in my pants with some pizza, a six pack, and side one of Zeppelin IV.

Sam : Well, at least I'm not afraid of flying.
Dean : Planes crash!
Sam : And apparently clowns kill!

Mr Cooper : You see, this place, it's a refuge for outcasts. Always has been. For folks that don't fit in nowhere else. But you two? You should go to school. Find a couple of girls. Have two point five kids. Live regular.
Sam : Sir? We don't want to go to school. And we don't want regular. We want this.

Ash : But if this fugly bastard raises his head, I'll know. I mean, I'm on it like Divine on dog dookie.

2x03 - Bloodlust

Sam : You know, if you two want to get a room, just let me know, Dean.

Sam : A couple of severed heads and a pile of dead cows and you're Mr. Sunshine.

Gordon : Well, lighten up a little, Sammy.
Sam : He's the only one who gets to call me that.

Dean : Sammy? Remind me to beat that buzzkill out of you later, all right?

Sam : You know, you slap on this big fake smile but I can see right through it. Because I know how you feel, Dean. Dad's dead. And he left a hole, and it hurts so bad you can't take it, but you can't just fill up that hole with whoever you want to. It's an insult to his memory.

Dean : What if we killed things that didn't deserve killing?

2x04 - Children Shouldn't Play With Dead Things

Neil : We've got booze, we've got chocolate, and, wait for it... tortured emo rock. Guaranteed cure for any broken heart.

Neil : I didn't realize the college employed grief counselors.
Dean : Oh yeah. Yeah, you talk, we listen. Or maybe throw in a little therapeutic collage, whatever jump-starts the healing.

Dean : What's dead should stay dead!

Sam : Dean, I don't scare easy, but man, you're scaring the crap out of me.

Sam : Stop. Please, Dean, it's killing you. Please. We've already lost Dad. We've lost Mom. I've lost Jessica. And now I'm going to lose you too?

Dean : Hello? Neil?! It's your grief counselors, we've come to hug.

Dean : You and Dad... you're the most important people in my life. And now... I never should have come back, Sam. It wasn't natural. And now look what's come of it. I was dead. And I should have stayed dead. You wanted to know how I was feeling. Well, that's it. So tell me. What could you possibly say to make that all right?

2x05 - Simon Said

Dean : There's gonna be hunters there, I don't know if, if, if going in and announcing that you're some supernatural freak with a, a demonic connection is the best thing, okay?
Sam : So I'm a freak now?
Dean : You've always been a freak.

Sam : Hey Ash. Um. We need your help.
Ash : Well, hell then. Guess I need my pants.

Dean : REO Speedwagon?
Jo : Damn right REO. Kevin Cronin sings it from the heart.
Dean : He sings it from the hair. There's a difference.

Dean : He's psychic. Kind of like you. Well, not really like you, but see, he thinks you're a murderer, and he's afraid that he's going to become one himself, 'cause you're all part of something that's terrible. And I hope to hell that he's wrong, but I'm starting to get a little scared that he might be right.

Weber : He came to me. In my dream. He said I was special. He told me he's got big plans for me. Wait 'till you see what's in store, Andy, for both of us! See, he's the one who told me I had a brother. A twin.

Sam : Right circumstances, everyone's capable of murder. Everyone. You know, maybe that's what the demon's doing. Pushing us. Finding ways to break us.

Ellen : You mind your tongue with me, boy. This isn't just your war, this is war. Now, something big and bad's coming and it's coming fast, and their side holds all the cards. Now, at best all we got is us. Together. No secrets or half-truths here.

2x06 - No Exit

Dean : Young girl's been kidnapped by an evil cult.
Sam : Yeah? Girl got a name?
Dean : Katie Holmes.

Dean : [To Jo] Sweetheart, this ain't gender studies. Women can do the job fine. Amateurs can't. You have no experience. What you do have is a bunch of half-baked romantic that some barflies put in your head.

Dean : Remember when I said you being bait was a bad plan? Now it's kind of the only one we got.

Sam : So? This job as glamorous as you thought it would be?
Jo : Well, except for all the pee-your-pants terror, yeah.

2x07 - The Usual Suspects

Dean : What do you think, Scully? You wanna check it out?
Sam : I'm not Scully, you're Scully.
Dean : No, I'm Mulder. You're a red-headed woman.

Dean : My name is Dean Winchester. I'm an Aquarius. I enjoy sunsets, long walks on the beach, and frisky women. And I did not kill anyone. But I know who did. Or rather what did. Of course it can't be for sure, because our investigation was interrupted. But our working theory was that we're looking for some kind of vengeful spirit.

Sam : You know? This is bothering me.
Ballard : Well, you are digging up a corpse.
Sam : No, not that. That's, uh, that's pretty par for the course, actually.

2x08 - Crossroad Blues

Dean : Dude, I'm like Dillinger or something.

Dean : Well, we know a little about a lot of things. Just enough to make us dangerous.

Dean : I usually like to be warned before I'm violated with demon tongue.

2x09 - Croatoan

Sam : [To Dean] Roanoke? Lost colony? Ring a bell? Dean, did you pay any attention in history class?

Sam : You might kill an innocent man, and you don't even care! You don't act like yourself anymore, Dean. Hell, you know what? You're acting like one of those things out there.

Duane : You were gonna shoot me!
Dean : You don't shut your pie hole, I still might.

Sam : This is the dumbest thing you’ve ever done.
Dean : I don’t know about that. Remember that waitress in Tampa?

Dean : I'm tired, Sam. I'm tired of this job, this life . . . this weight on my shoulders, man. I'm tired of it.

2x10 - Hunted

Ava : [To Sam] Okay, you know what? Screw you buddy, okay, cos I'm a secretary from Peoria and I'm not part of anything, okay? D'you see this? I am getting married in eight weeks. I am supposed to be at home, addressing invitations, which I am way behind on by the way, but instead I drove out here to save your weirdo ass, but if you just wanna stay here and die, fine. Me? I'm due back on planet Earth.

Sam: Are you okay?
Ava: Am I okay?
Sam: Yeah.
Ava: I just helped you steal some dead guy's confidential psych files. I'm awesome!

Ellen: Now, Dean, they say you can’t protect your loved ones forever. Well, I say screw that-- what else is family for?

Dean: What’s the point of saving the world if you can’t get a little nookie once in a while, huh?

2x11 - Playthings

Susan: I don't believe this.
Dean: Listen, sister, that car didn't try to run you down by itself, okay? I mean I guess it did, technically, but if a spirit can... forget it.

Dean: We gotta figure this out and fast. What d'ya find out about Granny?
Sam: (drunkenly) You're bossy.
Dean: What?!
Sam: You're bossy. And short... (chuckles)
Dean: Are you drunk?
Sam: Yeah! So? Stupid.

Dean: Of course, the most troubling question is why do these people assume we're gay?
Sam: Well, you are kind of butch. They probably think you're overcompensating.

Dean: Dude, this is sweet! I never get to work jobs like this.
Sam: Like what?
Dean: Old-school haunted houses. Secret passageways, sissy British accents. We might even get to run into Fred and Daphne while we're inside. Mmm, Daphne...love her.

2x12 - Nightshifter

Frannie: So, what's it like, being an FBI guy?
Dean: Well, it's dangerous, yeah. And the secrets we gotta keep, oh God, the secrets. But mostly it's... it's lonely.

Ronald: This is not a robbery! Everybody on the floor, now!

Frannie: So, what's it like, being an FBI guy?
Dean: Well, it's dangerous, yeah. And the secrets we gotta keep, oh God, the secrets. But mostly it's... it's lonely.

2x13 - Houses of the Holy

Dean: Man, you have got to try this because there really is magic in the magic fingers.
Sam: Dude. You're enjoying that way too much. It's kinda making me uncomfortable.

Sam: Dude, all right, I'll admit, we've gone pretty ghetto with spellwork before, but this takes the cake! I mean, a Spongebob placemat instead of an altar cloth?!
Dean: We'll just put it Spongebob-side down.

Dean: That lore about unicorns is true too. I hear they ride on silver moonbeams, and shoot rainbows out of their ass.

2x14 - Born Under A Bad Sign

Bobby: Don't try and con a con man.

Sam: (in a sing-song voice) My Daddy shot your Daddy in the head.

2x15 - Tall Tales

Dean: These punishments, they’re almost poetic. Well, actually they’d be more like a limerick, but still…

Sam: Dean. this is a very serious investigation. We don't have time for any of your blah blah blah blah. Blah blah blah blah. Blah... blah blah blah. Blah blah blah blah. Blah!

2x16 - Roadkill

Dean: Y'know, just once I'd like to round the corner and see a nice house.

Sam: It's an old country custom, Dean. Planting a tree as a grave-marker.
Dean: You're like a walking encyclopedia of weirdness.
Sam: Yeah, I know.

Molly: What happens if you burn their bones?
Sam: My dad always said it's like death for spirits. But the truth is, we never know.

2x17 - Heart

Sam: What were you doing with Kurt?
Madison: I don’t know. I mean, it’s not like he introduced himself like, “Hi, I’m possessive and controlling and I like to punch people, wanna be my girlfriend?”

Madison: You know for a stakeout, your car's a bit conspicuous.

Sam: Can I ask you a question? I, it's, it's a little personal.
Madison: You've seen my entire underwear collection. Go ahead.

2x18 - Hollywood Babylon

Brad: Uh, excuse me, green-shirt guy? Yeah, yeah, you, come here. Could you get me a smoothie from craft?
Dean: You want a what from who?

Tara: Doesn’t that sound silly? Why would a ghost be afraid of salt?

Sam: You know, maybe the spirits are trying to shut down the movie because they think it sucks. 'Cause, I mean, it kind of does.

Dean: What's a PA?
Sam: I think they're kinda like slaves.

2x19 - Folsom Prison Blues

Mara: Do you have any idea how much trouble you're in here?
Dean: I've got a vague notion.

Randall: Why you inside, kid?
Sam: Cause I got an idiot for a brother.
Randall: That’ll do it.

Dean: Don't worry, Sam. I promise I won't trade you for smokes.

Hendrickson: You think you're funny?
Dean: I think I'm adorable.

2x20 - What Is and What Should Never Be

Dean: You should have seen it, Sam... our lives... you were such a wussy.

Carmen: What do you say later we get you a cheeseburger?
Dean: Oh god yes. How’d I end up with such a cool chick?
Carmen: I just got low standards.

Sam: I thought it was supposed to be a fantasy.
Dean: It wasn't. If Mom never died, you and me would've never gone hunting and you and me, you know.
Sam: Yeah. Well, I'm glad we did.

Dean: Bitch.
Sam: What're you calling me a bitch for?
Dean: You're supposed to say "jerk."
Sam: What?
Dean: Never mind.

2x21 - All Hell Breaks Loose Part One

Ava: Sam, psychic abilities and spoon-bending... it's one thing. But demons?

Sam: Andy, you still with me, or what?
Andy: Give me a minute, I'm still working through "Demons are real."

Andy: I've been practicing, training my brain like meditation, right, so now it's not just thoughts I can beam out, but images, too, like anything I want. It's like bam, people they see it. This one guy I know, total dick. I use it on him... gay porn. All hours of the day.

Jake: Salt is a weapon?
Sam: It's a brave new world.

2x22 - All Hell Breaks Loose Part Two

Dean: When you were little, couldn't have been more than five, you just started asking questions. How come we didn't have a mom. Why did we always have to move around. Where's Dad. I remember I begged you. 'Quit asking, Sammy. You don't want to know.' I just wanted you to be a kid. Just for a little while longer. Always tried to protect you. Keep you safe. Dad didn't even have to tell me. It's just always my responsibility, you know? It's like I had one job. I had one job, and I screwed it up. I blew it, and for that, I'm sorry. I guess that’s what I do. I let down the people I love. Y’know, I let Dad down, and now I guess I’m just supposed to let you down, too. How can I? How am I supposed to live with that? What am I supposed to do? Sammy? What am I supposed to do?

Yellow-Eyed Demon: So, Dean. I gotta thank you. You see, demons can't resurrect people unless a deal is made. I know, red tape, it'll make you nuts. But thanks to you, Sammy's back in rotation. I wasn't counting on that, but I'm glad. I liked him better than Jake anyhow.

Yellow-Eyed Demon: Boys shouldn't play with Daddy's guns.

Ellen: A lot of good people died in there, and I got to live. Lucky me

Dean: We've got work to do.